منابع مشابه
The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis.
BACKGROUND Oxidative stress is considered to be involved in the establishment and development of endometriosis. Thioredoxin (TRX) is an endogenous redox regulator that protects cells against oxidative stress, and TRX-binding protein-2 (TBP-2) is a negative regulator of TRX in the biological function and expression. The aim of this study was to investigate the roles of TRX and TBP-2 in the patho...
متن کاملExpression of thioredoxin and thioredoxin-binding protein-2 in the liver of patients with chronic hepatitis C as a predictor of response to interferon therapy.
Oxidative stress contributes to the pathogenesis of various hepatic injuries. Thioredoxin (TRX) is an indicator of oxidative stress, reported to be increased in the serum of patients with chronic hepatitis C with the progression of fibrosis. The aim of this study was to evaluate the clinical significance of the expression of TRX and thioredoxin-binding protein-2 (TBP-2), which is a negative reg...
متن کاملThe Human Thioredoxin System: Modifications and Clinical Applications
The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. Trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( Trp-Cys-Gly-Pro- Cys-Lys-). Different factors are involved in the regulation of T...
متن کاملThioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus
Thioredoxin binding protein -2/ thioredoxin interacting protein is an α-arrestin protein that has attracted much attention as a multifunctional regulator. Thioredoxin binding protein -2 expression is downregulated in tumor cells and the level of thioredoxin binding protein is correlated with clinical stage of cancer. Mice with mutations or knockout of the thioredoxin binding protein -2 gene are...
متن کاملIsolation and characterization of calf liver thioredoxin.
The reduced form of thioredoxin, a low molecular weight hydrogen transport protein, was isolated from calf liver. The purification involved heat treatment and chromatography on DEAE-cellulose, Sephadex G-SO, and CM-cellulose, and it resulted in an apparently pure protein after a 4,000-fold purification with a final yield of 30%. The thioredoxin preparation obtained was homogeneous as judged by ...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2008
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.102